Balancing Non-Equilibrium Driving with Nucleotide Selectivity at Kinetic Checkpoints in Polymerase Fidelity Control

High fidelity gene transcription and replication require kinetic discrimination of nucleotide substrate species by RNA and DNA polymerases under chemical non-equilibrium conditions. It is known that sufficiently large free energy driving force is needed for each polymerization or elongation cycle to...

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Bibliographic Details

Published in:	Entropy
Main Authors:	Chunhong Long, Jin Yu
Format:	Article
Language:	English
Published:	MDPI AG 2018-04-01
Subjects:	polymerase non-equilibrium kinetic checkpoint nucleotide selection fidelity control
Online Access:	http://www.mdpi.com/1099-4300/20/4/306