MYC regulates metabolism through vesicular transfer of glycolytic kinases

Amplification of the proto-oncogene MYCN is a key molecular aberration in high-risk neuroblastoma and predictive of poor outcome in this childhood malignancy. We investigated the role of MYCN in regulating the protein cargo of extracellular vesicles (EVs) secreted by tumour cells that can be interna...

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Bibliographic Details

Published in:	Open Biology
Main Authors:	Alexia Tsakaneli, Victor Corasolla Carregari, Martina Morini, Alessandra Eva, Giuliana Cangemi, Olesya Chayka, Evgeny Makarov, Sandra Bibbò, Emily Capone, Gianluca Sala, Vincenzo De Laurenzi, Evon Poon, Louis Chesler, Luisa Pieroni, Martin R. Larsen, Giuseppe Palmisano, Arturo Sala
Format:	Article
Language:	English
Published:	The Royal Society 2021-12-01
Subjects:	extracellular vesicles MYC MYCN neuroblastoma Warburg effect
Online Access:	https://royalsocietypublishing.org/doi/10.1098/rsob.210276