Engineering PD-1-targeted small protein variants for in vitro diagnostics and in vivo PET imaging

Abstract Background Programmed cell death 1 (PD-1) belongs to immune checkpoint proteins ensuring negative regulation of the immune response. In non-small cell lung cancer (NSCLC), the sensitivity to treatment with anti-PD-1 therapeutics, and its efficacy, mostly correlated with the increase of tumo...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Joanna Maria Mierzwicka, Hana Petroková, Leona Rašková Kafková, Petr Kosztyu, Jiří Černý, Milan Kuchař, Miloš Petřík, Kateřina Bendová, Kristýna Krasulová, Yaroslava Groza, Lucie Vaňková, Shiv Bharadwaj, Natalya Panova, Michal Křupka, Jozef Škarda, Milan Raška, Petr Malý
Format:	Article
Language:	English
Published:	BMC 2024-05-01
Subjects:	Immune checkpoint Programmed cell death 1 Non-small cell lung cancer Cancer diagnostic Combinatorial library Protein engineering
Online Access:	https://doi.org/10.1186/s12967-024-05210-x