Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging

Abstract Background With advanced maternal age, abnormalities during oocyte meiosis increase significantly. Aneuploidy is an important reason for the reduction in the quality of aged oocytes. However, the molecular mechanism of aneuploidy in aged oocytes is far from understood. Histone acetyltransfe...

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Bibliographic Details

Published in:	Reproductive Biology and Endocrinology
Main Authors:	Bichun Guo, Sainan Zhang, Shanshan Wang, Huidan Zhang, Junshun Fang, Nannan Kang, Xin Zhen, Yang Zhang, Jidong Zhou, Guijun Yan, Haixiang Sun, Lijun Ding, Chuanming Liu
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Subjects:	Ovarian aging HAT1 Meiotic defects FoxO1 AREG
Online Access:	https://doi.org/10.1186/s12958-023-01147-w