The ribosome collision sensor Hel2 functions as preventive quality control in the secretory pathway

Summary: Ribosome collision because of translational stalling is recognized as a problematic event in translation by the E3 ubiquitin ligase Hel2, leading to non-canonical subunit dissociation followed by targeting of the faulty nascent peptides for degradation. Although Hel2-mediated quality contro...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Yoshitaka Matsuo, Toshifumi Inada
Format:	Article
Language:	English
Published:	Elsevier 2021-03-01
Subjects:	Hel2 ribosome ubiquitination ribosome stalling ribosome collision quality control SRP
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124721001911