Improving hematopoietic differentiation from human induced pluripotent stem cells by the modulation of Hippo signaling with a diarylheptanoid derivative

Abstract Background The diarylheptanoid ASPP 049 has improved the quality of adult hematopoietic stem cell (HSC) expansion ex vivo through long-term reconstitution in animal models. However, its effect on hematopoietic regeneration from human induced pluripotent stem cells (hiPSCs) is unknown. Metho...

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الحاوية / القاعدة:	Stem Cell Research & Therapy
المؤلفون الرئيسيون:	Umnuaychoke Thongsa-ad, Anongnat Wongpan, Wasinee Wongkummool, Phaewa Chaiwijit, Kwanchanok Uppakara, Gorawin Chaiyakitpattana, Passanan Singpant, Pirut Tong-ngam, Amnat Chukhan, Wachirachai Pabuprappap, Sirapope Wongniam, Apichart Suksamrarn, Suradej Hongeng, Usanarat Anurathapan, Kasem Kulkeaw, Alisa Tubsuwan, Kanit Bhukhai
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	BMC 2024-03-01
الموضوعات:	Diarylheptanoid Human induced pluripotent stem cells Primitive hematopoietic stem and progenitor cells Hippo signaling pathway
الوصول للمادة أونلاين:	https://doi.org/10.1186/s13287-024-03686-4