Reverse engineering morphogenesis through Bayesian optimization of physics-based models
Abstract Morphogenetic programs coordinate cell signaling and mechanical interactions to shape organs. In systems and synthetic biology, a key challenge is determining optimal cellular interactions for predicting organ shape, size, and function. Physics-based models defining the subcellular force di...
| Published in: | npj Systems Biology and Applications |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-05-01
|
| Online Access: | https://doi.org/10.1038/s41540-024-00375-z |