The Actin-Binding Protein Cortactin Promotes Sepsis Severity by Supporting Excessive Neutrophil Infiltration into the Lung

Sepsis is a systemic infection that can lead to multi-organ failure. It is characterised by an uncontrolled immune response with massive neutrophil influx into peripheral organs. Neutrophil extravasation into tissues depends on actin remodeling and actin-binding proteins such as cortactin, which is...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Nathaniel L. Lartey, Hilda Vargas-Robles, Idaira M. Guerrero-Fonseca, Alexander García-Ponce, Citlaltepetl Salinas-Lara, Klemens Rottner, Michael Schnoor
Format:	Article
Language:	English
Published:	MDPI AG 2022-04-01
Subjects:	sepsis acute lung injury cytokine storm actin-binding protein cortactin neutrophil diapedesis
Online Access:	https://www.mdpi.com/2227-9059/10/5/1019