GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons.
The PI3K-dependent activation of AKT results in the inhibition of GSK3β in most signaling pathways. These kinases regulate multiple neuronal processes including the control of synapse number as shown for Drosophila and rodents. Alzheimer disease's patients exhibit high levels of circulating GSK...
| Published in: | PLoS ONE |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Online Access: | http://europepmc.org/articles/PMC4357437?pdf=render |