Effect of Lyophilization on Stability of PEG-Protein Conjugate: A Case Study with Peginterferon alfa-2b

Abstract The purpose of the present study was to develop stable lyophilized formulation of peginterferon alfa-2b which is acquiescent to the short lyophilization process. The present study evaluates the effect of buffering components and cryoprotectant(s) on depegylation of the peginterferon alfa-2b...

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Bibliographic Details

Published in:	Brazilian Journal of Pharmaceutical Sciences
Main Authors:	Patel Chintan, Patel Gayatri
Format:	Article
Language:	English
Published:	Universidade de São Paulo 2023-04-01
Subjects:	Depegylation Lyophilization Stability Residual moisture content Peginterferon alfa-2b
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502023000100326&tlng=en