Methylmercury (MeHg) transcriptionally regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) in Hepa-1c1c7 cells

The detoxification of quinones through NAD(P)H:quinone oxidoreductase (NQO1) is a crucial mechanism to maintain cellular homeostasis. The exposure to heavy metals, specifically methylmercury (MeHg), induces several antioxidant enzymes, including NQO1. The nuclear factor erythroid 2-related factor-2...

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Bibliographic Details

Published in:	Current Research in Toxicology
Main Authors:	Mohammed A. Alqahtani, Mahmoud A. El-Ghiaty, Sara R. El-Mahrouk, Ayman O.S. El-Kadi
Format:	Article
Language:	English
Published:	Elsevier 2023-01-01
Subjects:	Methylmercury Mercury NQO1 NRF2 AHR ARE
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666027X23000245