A simplified herbal decoction attenuates myocardial infarction by regulating macrophage metabolic reprogramming and phenotypic differentiation via modulation of the HIF-1α/PDK1 axis

Abstract Background Myocardial infarction (MI) poses a global public health challenge, often associated with elevated mortality rates and a grim prognosis. A crucial aspect of the inflammatory injury and healing process post-MI involves the dynamic differentiation of macrophages. A promising strateg...

Full description

Bibliographic Details

Published in:	Chinese Medicine
Main Authors:	Zhi-jun Lin, Xin Dong, Huan He, Jia-lin Jiang, Zhuo-ji Guan, Xuan Li, Lu Lu, Huan Li, Yu-sheng Huang, Shao-xiang Xian, Zhong-qi Yang, Zi-xin Chen, Hong-cheng Fang, Ling-jun Wang
Format:	Article
Language:	English
Published:	BMC 2024-05-01
Subjects:	Nuanxinkang (NXK) Myocardial Infarction (MI) Energy metabolism Macrophages polarization
Online Access:	https://doi.org/10.1186/s13020-024-00933-x