Transcriptomic analysis identifies lactoferrin-induced quiescent circuits in neonatal macrophages

IntroductionUpon birth, a hitherto naïve immune system is confronted with a plethora of microbial antigens due to intestinal bacterial colonization. To prevent excessive inflammation and disruption of the epithelial barrier, physiological mechanisms must promote immune-anergy within the neonatal gut...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Michael Eigenschink, Isabelle Wessely, Marco Dijmarescu, Elisabeth Förster-Waldl, Alex Farr, Herbert Kiss, Angelika Berger, Lukas Wisgrill
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Subjects:	human lactoferrin neonatal immune system immune tolerance macrophage function microbiome necrotizing enterocolitis
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1276173/full