PP1/PNUTS phosphatase binds the restrictor complex and stimulates RNA Pol II transcription termination

Summary: The restrictor ZC3H4/WDR82 terminates antisense transcription from bidirectional promoters, but its mechanism is poorly understood. We report that ZC3H4/WDR82 immunoprecipitates with PP1 phosphatase and its nuclear targeting subunit, PP1 phosphatase nuclear targeting subunit (PNUTS), which...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Benjamin Erickson, Roman Fedoryshchak, Nova Fong, Ryan Sheridan, Keira Y. Larson, Anthony J. Saviola, Stephane Mouilleron, Kirk C. Hansen, Richard Treisman, David L. Bentley
Format:	Article
Language:	English
Published:	Elsevier 2025-05-01
Subjects:	CP: Molecular biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124725003353