Retinal degeneration driven by brain-derived neurotrophic factor deficiency in microglia and T-lymphocytes

Abstract Neurodegenerative diseases, such as glaucoma or multiple sclerosis, are characterized by progressive neuronal loss involving diverse pathogenic mechanisms. The brain-derived neurotrophic factor (BDNF) has been implicated in neuroprotection and neural plasticity, yet its regulation and invol...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Sabrina Reinehr, Julia P. Zehge, Katharina Klöster, Maike Mueller, Hasan H. Hendek, Michael Sendtner, H. Burkhard Dick, Ralf Gold, Stephanie C. Joachim, Simon Faissner
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-10-01
Subjects:	Astrogliosis Brain-derived neurotrophic factor Glaucoma Microglia Multiple sclerosis Neurodegeneration
Online Access:	https://doi.org/10.1038/s41598-025-21423-6