Rigid Tissue Increases Cytoplasmic pYAP Expression in Pre-Malignant Stage of Lung Squamous Cell Carcinoma (SCC) In Vivo

Increased tissue rigidity is able to activate the Hippo signaling pathway, leading to YAP inactivation by phosphorylation and translocation into the cytoplasm. Accumulating evidence suggests that cytoplasmic pYAP serves as a tumor suppressor and could be a prognostic biomarker for several solid canc...

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Bibliographic Details

Published in:	Current Issues in Molecular Biology
Main Authors:	Muhammad Asyaari Zakaria, May Chee Kiew, Nor Fadilah Rajab, Eng Wee Chua, Siti Fathiah Masre
Format:	Article
Language:	English
Published:	MDPI AG 2022-09-01
Subjects:	lung squamous cell carcinoma (SCC) pre-malignant phosphorylated Yes-associated protein (pYAP) tissue rigidity epithelium thickness cell proliferation
Online Access:	https://www.mdpi.com/1467-3045/44/10/310