CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling

Chemotactic responses in bacteria require large, highly ordered arrays of sensory proteins to mediate the signal transduction that ultimately controls cell motility. A mechanistic understanding of the molecular events underlying signaling, however, has been hampered by the lack of a high-resolution...

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Bibliographic Details

Published in:	eLife
Main Authors:	C Keith Cassidy, Benjamin A Himes, Frances J Alvarez, Jun Ma, Gongpu Zhao, Juan R Perilla, Klaus Schulten, Peijun Zhang
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2015-11-01
Subjects:	cryo-electron tomography bacterial chemotaxis molecular dynamics simulation lipid monolayer sub-tomogram cross-linking
Online Access:	https://elifesciences.org/articles/08419