Mechanistic insights into the sleep-glymphopathy-cerebral small vessel disease loop: implications for epilepsy pathophysiology and therapy

Epilepsy is the second most common neurological disorder and affects approximately 50 million people worldwide. Despite advances in antiepileptic therapy, about 30% of patients develop refractory epilepsy. Recent studies have shown sleep, glymphatic function, cerebral small vessel disease (CSVD), an...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Zaw Myo Hein, Zaid Adnan Subhi Al-Zaghal, Mazira Muhammad Ghazali, Usman Jaffer, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Muhammad Danial Che Ramli, Che Mohd Nasril Che Mohd Nassir
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	sleep glymphatic system cerebral small vessel disease epilepsy therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2025.1546482/full