Impact of the IL-15 superagonist N-803 on lymphatic reservoirs of HIV

BACKGROUND NK cell function is impaired in people with HIV (PWH), hindering their potential to reduce the lymphoid tissue (LT) reservoir. The IL-15 superagonist N-803 has been shown to enhance NK and T cell function and thus may reduce viral reservoirs.METHODS To determine the impact of N-803 on LTs...

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Bibliographic Details

Published in:	JCI Insight
Main Authors:	Joshua Rhein, Jeffrey G. Chipman, Gregory J. Beilman, Ross Cromarty, Kevin Escandón, Jodi Anderson, Garritt Wieking, Jarrett Reichel, Rodolfo Batres, Alexander Khoruts, Christopher M. Basting, Peter Hinderlie, Zachary B. Davis, Anne Eaton, Byron P. Vaughn, Elnaz Eilkhani, Jeffrey T. Safrit, Patrick Soon-Shiong, Jason V. Baker, Nichole R. Klatt, Steven G. Deeks, Jeffrey S. Miller, Timothy W. Schacker
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2025-07-01
Subjects:	AIDS/HIV Infectious disease
Online Access:	https://doi.org/10.1172/jci.insight.190831