RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation

The RAS-MAPK-pathway is aberrantly regulated in cancer and developmental diseases called RASopathies. While typically the impact of Ras on the proliferation of various cancer cell lines is assessed, it is poorly established how Ras affects cellular differentiation. Here we implement the C2C12 myobla...

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Bibliographic Details

Published in:	European Journal of Cell Biology
Main Authors:	Rohan Chippalkatti, Bianca Parisi, Farah Kouzi, Christina Laurini, Nesrine Ben Fredj, Daniel Kwaku Abankwa
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	Ras Cancer RASopathy Flow cytometry Inhibitors Differentiation
Online Access:	http://www.sciencedirect.com/science/article/pii/S0171933524000426