HMTase Inhibitors as a Potential Epigenetic-Based Therapeutic Approach for Friedreich’s Ataxia

Friedreich’s ataxia (FRDA) is a progressive neurodegenerative disorder caused by a homozygous GAA repeat expansion mutation in intron 1 of the frataxin gene (FXN), which instigates reduced transcription. As a consequence, reduced levels of frataxin protein lead to mitochondrial iron accumulation, ox...

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Bibliographic Details

Published in:	Frontiers in Genetics
Main Authors:	Mursal Sherzai, Adamo Valle, Nicholas Perry, Ester Kalef-Ezra, Sahar Al-Mahdawi, Mark Pook, Sara Anjomani Virmouni
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-06-01
Subjects:	FRDA Friedreich ataxia frataxin FXN GAA repeat HMTase inhibitor
Online Access:	https://www.frontiersin.org/article/10.3389/fgene.2020.00584/full