The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts.

Accumulation of somatic changes, due to environmental and endogenous lesions, in the human genome is associated with aging and cancer. Understanding the impacts of these processes on mutagenesis is fundamental to understanding the etiology, and improving the prognosis and prevention of cancers and o...

Full description

Bibliographic Details

Published in:	PLoS Genetics
Main Authors:	Natalie Saini, Steven A Roberts, Leszek J Klimczak, Kin Chan, Sara A Grimm, Shuangshuang Dai, David C Fargo, Jayne C Boyer, William K Kaufmann, Jack A Taylor, Eunjung Lee, Isidro Cortes-Ciriano, Peter J Park, Shepherd H Schurman, Ewa P Malc, Piotr A Mieczkowski, Dmitry A Gordenin
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-10-01
Online Access:	https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006385&type=printable