Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells

Capillary malformation-arteriovenous malformation (CM-AVM) is a blood vascular anomaly caused by inherited loss-of-function mutations in RASA1 or EPHB4 genes, which encode p120 Ras GTPase-activating protein (p120 RasGAP/RASA1) and Ephrin receptor B4 (EPHB4). However, whether RASA1 and EPHB4 function...

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Bibliographic Details

Published in:	JCI Insight
Main Authors:	Di Chen, Elizabeth D. Hughes, Thomas L. Saunders, Jiangping Wu, Magda N. Hernandez Vasquez, Taija Makinen, Philip D. King
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2022-02-01
Subjects:	Angiogenesis Vascular biology
Online Access:	https://doi.org/10.1172/jci.insight.156928