The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3

Abstract The intracellular bacterial pathogen Coxiella burnetii evades the host response by secreting effector proteins that aid in establishing a replication-friendly niche. Bacterial filamentation induced by cyclic AMP (Fic) enzymes can act as effectors by covalently modifying target proteins with...

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Bibliographic Details

Published in:	Communications Biology
Main Authors:	Dorothea Höpfner, Adam Cichy, Vivian Pogenberg, Christoph Krisp, Soraya Mezouar, Nina C. Bach, Jan Grotheer, Sandra Madariaga Zarza, Eric Martinez, Matteo Bonazzi, Matthias J. Feige, Stephan A. Sieber, Hartmut Schlüter, Aymelt Itzen
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-11-01
Online Access:	https://doi.org/10.1038/s42003-023-05494-7