Epigenetic modulations in cancer: predictive biomarkers and potential targets for overcoming the resistance to topoisomerase I inhibitors

AbstractIntroduction Altered epigenetic map is frequently observed in cancer and recent investigations have demonstrated a pertinent role of epigenetic modifications in the response to many anticancer drugs including the DNA damaging agents. Topoisomerase I (Top I) is a well-known nuclear enzyme tha...

Full description

Bibliographic Details

Published in:	Annals of Medicine
Main Authors:	Moustafa M. Madkour, Wafaa S. Ramadan, Ekram Saleh, Raafat El-Awady
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Subjects:	Cancer DNA methylation epigenetic histone modifications noncoding RNAs resistance
Online Access:	https://www.tandfonline.com/doi/10.1080/07853890.2023.2203946