Noncanonical feedback loop between “RIP3–MLKL” and “4EBP1–eIF4E” promotes neuronal necroptosis

Abstract Stroke is a leading risk factor for disability and death. Necroptosis is involved in stroke pathogenesis. However, the molecular mechanisms underlying necroptosis in stroke remain unclear. The mammalian target of rapamycin complex 1 (mTORC1) modulates necroptosis in the gut epithelium. Euka...

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Bibliographic Details

Published in:	MedComm
Main Authors:	Shuchao Wang, Yun Zhang, Meijuan Wang, Zhihao Zhai, Yating Tan, Weiye Xu, Xiaozhen Ren, Ximin Hu, Jinyou Mo, Jia Liu, Yunfeng Yang, Dan Chen, Bing Jiang, Hualin Huang, Jufang Huang, Kun Xiong
Format:	Article
Language:	English
Published:	Wiley 2025-03-01
Subjects:	4EBP1 eIF4E MLKL necroptosis RIP3 stroke
Online Access:	https://doi.org/10.1002/mco2.70107