Nanoneedles Induce Targeted siRNA Silencing of p16 in the Human Corneal Endothelium

Abstract Nanoneedles can target nucleic acid transfection to primary cells at tissue interfaces with high efficiency and minimal perturbation. The corneal endothelium is an ideal target for nanoneedle‐mediated RNA interference therapy aimed at enhancing its proliferative capacity, necessary for tiss...

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Bibliographic Details
Published in:Advanced Science
Main Authors: Eleonora Maurizi, Davide Alessandro Martella, Davide Schiroli, Alessia Merra, Salman Ahmad Mustfa, Graziella Pellegrini, Claudio Macaluso, Ciro Chiappini
Format: Article
Language:English
Published: Wiley 2022-11-01
Subjects:
gene therapy
nanoneedles
porous silicon
regenerative medicine
siRNA
Online Access:https://doi.org/10.1002/advs.202203257

Internet

https://doi.org/10.1002/advs.202203257

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