Methylglyoxal from gut microbes boosts radiosensitivity and radioimmunotherapy in rectal cancer by triggering endoplasmic reticulum stress and cGAS-STING activation

Background Preoperative radiation therapy (preRT) is a fundamental aspect of neoadjuvant treatment for rectal cancer (RC), but the response to this treatment remains unsatisfactory. The combination of radiation therapy (RT) and immunotherapy (iRT) presents a promising approach to cancer treatment, t...

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Bibliographic Details

Published in:	Journal for ImmunoTherapy of Cancer
Main Authors:	Lei Wang, Kai Wang, Jinluan Li, Junxin Wu, Libin Liu, Da Zhang, Jianji Pan, Han Zhou, Zhiwen Lin, Chenwei Jiang, Xingte Chen, Lingdong Shao
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2023-11-01
Online Access:	https://jitc.bmj.com/content/11/11/e007840.full