T Cell-Association of Carboxy-Terminal Dendrimers with Different Bound Numbers of Phenylalanine and Their Application to Drug Delivery

T cells play important roles in various immune reactions, and their activation is necessary for cancer immunotherapy. Previously, we showed that polyamidoamine (PAMAM) dendrimers modified with 1,2-cyclohexanedicarboxylic acid (CHex) and phenylalanine (Phe) underwent effective uptake by various immun...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Hiroya Shiba, Tomoka Hirose, Yunshen Fu, Masataka Michigami, Ikuo Fujii, Ikuhiko Nakase, Akikazu Matsumoto, Chie Kojima
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Subjects:	dendrimer drug delivery system immune cells phenylalanine T cells
Online Access:	https://www.mdpi.com/1999-4923/15/3/888