Cyclophilin D knockout significantly prevents HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH.

A family of Peptidyl-prolyl isomerases (PPIases), called Cyclophilins, localize to numerous intracellular and extracellular locations where they contribute to a variety of essential functions. We previously reported that non-immunosuppressive pan-cyclophilin inhibitor drugs like reconfilstat (CRV431...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Winston T Stauffer, Michael Bobardt, Daren R Ure, Robert T Foster, Philippe Gallay
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2024-01-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0301711&type=printable