Defining intra-tumoral and systemic immune biomarkers for locally advanced head-and-neck cancer – detailed protocol of a prospective, observatory multicenter trial (ImmunBioKHT) and first results of the immunophenotyping of the patients’ peripheral blood

The approval and effectiveness of immune checkpoint inhibitors in head-and-neck squamous cell carcinoma (HNSCC) highlights the role of the immune system in this tumor entity. HNSCCs not only interacts with the immune system in the tumor tissue, but also induce systemic effects that may be additional...

Full description

Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Anna-Jasmina Donaubauer, Benjamin Frey, Manuel Weber, Moritz Allner, Christoph Vogl, Omar Almajali, Lukas Kuczera, Henriette Tamse, Matthias Balk, Sarina Müller, Markus Eckstein, Lilli Zülch, Lia Mogge, Thomas Weissmann, Rainer Fietkau, Marco Kesting, Heinrich Iro, Udo S. Gaipl, Markus Hecht, Antoniu-Oreste Gostian
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-09-01
Subjects:	HNSCC liquid biopsy immune monitoring immunological biomarker prospective clinical trial
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1451035/full