Gallium disrupts endoplasmic reticulum iron metabolism to induce lipid metabolic reprogramming in glioblastoma cells

Summary: Gallium based therapeutic strategies are thought to be an effective means to promote tumor cell killing that are currently being investigated in glioblastoma. Gallium is a group IIIa metal that is redox inactive, however, its atomic similarity to iron allows it to serve as an iron mimic tha...

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Bibliographic Details

Published in:	iScience
Main Authors:	Michael S. Petronek, Jeffrey M. Stolwijk, Amira Zaher, Stephenson B. Owusu, John Cooke, Akalanka B. Ekanayake, Alexei V. Tivanski, Jingyun Lee, Cristina M. Furdui
Format:	Article
Language:	English
Published:	Elsevier 2025-05-01
Subjects:	Biochemistry Molecular biology Neuroscience Immunology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004225006650