Human PXR Signaling Exacerbates Ethanol-induced Liver Injury in Females: Evidence From Mouse Models and Human Alcohol-associated Liver Disease CohortsSummary

Background & Aims: Alcohol-associated liver disease (ALD), resulting from excessive alcohol consumption, manifests with greater severity in females. The pregnane X receptor (PXR), a xenobiotic nuclear receptor critical for toxin defense, has been implicated in ALD; however, the mechanisms un...

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Bibliographic Details

Published in:	Cellular and Molecular Gastroenterology and Hepatology
Main Authors:	Malvin Ofosu-Boateng, Sora Choi, Sarah Kim, Elizabeth Twum, Daniel O. Nnamani, Lidya H. Gebreyesus, Suryakant Niture, Nour Yadak, Deepak Kumar, Frank J. Gonzalez, Suthat Liangpunsakul, Julia Yue Cui, Maxwell A. Gyamfi
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	Alcohol Nuclear Receptors Pregnane X Receptor Steatosis Sexual Dimorphism
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352345X25001304