Cooperative RNA degradation stabilizes intermediate epithelial-mesenchymal states and supports a phenotypic continuum

Summary: Multiple intermediate epithelial-mesenchymal transition (EMT) states reflecting hybrid epithelial and mesenchymal phenotypes were observed in physiological and pathological conditions. Previous theoretical models explaining multiple EMT states rely on regulatory loops involving transcriptio...

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Bibliographic Details

Published in:	iScience
Main Authors:	Benjamin Nordick, Mary Chae-Yeon Park, Vito Quaranta, Tian Hong
Format:	Article
Language:	English
Published:	Elsevier 2022-10-01
Subjects:	Molecular mechanism of gene regulation Mathematical biosciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004222014961