Suboptimal extracellular pH values alter DNA damage response to induced double‐strand breaks

Conditions leading to unrepaired DNA double‐stranded breaks are potent inducers of genetic instability. Systemic conditions may lead to fluctuation of hydrogen ions in the cellular microenvironment, and we show that small variations in extracellular pH, termed suboptimal pHe, can decrease the effici...

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Bibliographic Details

Published in:	FEBS Open Bio
Main Authors:	Julien Massonneau, Camille Ouellet, Fabrice Lucien, Claire M. Dubois, Jessica Tyler, Guylain Boissonneault
Format:	Article
Language:	English
Published:	Wiley 2018-03-01
Subjects:	DNA double‐stranded breaks DNA repair genetic instability histones pH
Online Access:	https://doi.org/10.1002/2211-5463.12384