Integrative genomic analysis reveals low T-cell infiltration as the primary feature of tobacco use in HPV-positive oropharyngeal cancer

Summary: Although tobacco use is an independent adverse prognostic feature in HPV(+) oropharyngeal squamous cell carcinoma (OPSCC), the biologic features associated with tobacco use have not been systematically investigated. We characterized genomic and immunologic features associated with tobacco u...

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Bibliographic Details

Published in:	iScience
Main Authors:	Benjamin M. Wahle, Paul Zolkind, Ricardo J. Ramirez, Zachary L. Skidmore, Sydney R. Anderson, Angela Mazul, D. Neil Hayes, Vlad C. Sandulache, Wade L. Thorstad, Douglas Adkins, Obi L. Griffith, Malachi Griffith, Jose P. Zevallos
Format:	Article
Language:	English
Published:	Elsevier 2022-05-01
Subjects:	Oncology Immunology Genomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004222004862