Role of Matrix Metalloproteinase-2 in Eosinophil-Mediated Airway Remodeling

Airway remodeling is responsible for the progressive decline of lung function in bronchial asthma. Matrix metalloproteinase-2 and fibroblast-to-myofibroblast transition are involved in tissue remodeling. Here we evaluated whether eosinophils play a role in fibroblasts-to-myofibroblasts transition an...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yu Kuwabara, Tetsu Kobayashi, Corina N. D'Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Kota Nishihama, Atsuro Takeshita, Hajime Fujimoto, Mizuho Nagao, Takao Fujisawa, Esteban C. Gabazza
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-09-01
Subjects:	tissue remodeling matrix metalloproteinases bronchial asthma eosinophils airways fibroblasts
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02163/full