Radiation induces NORAD expression to promote ESCC radiotherapy resistance via EEPD1/ATR/Chk1 signalling and by inhibiting pri-miR-199a1 processing and the exosomal transfer of miR-199a-5p

Abstract Background Radioresistance, a poorly understood phenomenon, results in the failure of radiotherapy and subsequent local recurrence, threatening a large proportion of patients with ESCC. To date, lncRNAs have been reported to be involved in diverse biological processes, including radioresist...

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Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Yuchen Sun, Jizhao Wang, Yuan Ma, Jing Li, Xuanzi Sun, Xu Zhao, Xiaobo Shi, Yunfeng Hu, Fengyi Qu, Xiaozhi Zhang
Format:	Article
Language:	English
Published:	BMC 2021-09-01
Subjects:	Esophageal squamous cell carcinoma Radioresistance NORAD Pri-miR-199a1 EEPD1
Online Access:	https://doi.org/10.1186/s13046-021-02084-5