Targeting RPA promotes autophagic flux and the antitumor response to radiation in nasopharyngeal carcinoma

Abstract Background Autophagy is involved in nasopharyngeal carcinoma (NPC) radioresistance. Replication protein A 1 (RPA1) and RPA3, substrates of the RPA complex, are potential therapeutic targets for reversing NPC radioresistance. Nevertheless, the role of RPA in autophagy is not adequately under...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Yanchun Feng, Yingming Jiang, Jun Liu, Jiaqi Liu, Mengchen Shi, Junxiong Chen, Jingdan Zhang, Yu Tian, Xiangling Yang, Huanliang Liu
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Subjects:	RPA Nasopharyngeal carcinoma Autophagy Radiotherapy
Online Access:	https://doi.org/10.1186/s12967-023-04574-w