Whole genome sequencing analysis identifies sex differences of familial pattern contributing to phenotypic diversity in autism

Abstract Background Whole-genome sequencing (WGS) analyses have found higher genetic burden in autistic females compared to males, supporting higher liability threshold in females. However, genomic evidence of sex differences has been limited to European ancestry to date and little is known about ho...

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Bibliographic Details

Published in:	Genome Medicine
Main Authors:	Soo-Whee Kim, Hyeji Lee, Da Yea Song, Gang-Hee Lee, Jungeun Ji, Jung Woo Park, Jae Hyun Han, Jee Won Lee, Hee Jung Byun, Ji Hyun Son, Ye Rim Kim, Yoojeong Lee, Jaewon Kim, Ashish Jung, Junehawk Lee, Eunha Kim, So Hyun Kim, Jeong Ho Lee, F. Kyle Satterstrom, Santhosh Girirajan, Anders D. Børglum, Jakob Grove, Eunjoon Kim, Donna M. Werling, Hee Jeong Yoo, Joon-Yong An
Format:	Article
Language:	English
Published:	BMC 2024-09-01
Subjects:	Whole-genome sequencing Autism Sex difference Phenotypic diversity Familial pattern Polygenic burden
Online Access:	https://doi.org/10.1186/s13073-024-01385-6