Effect of Span 20 Feeding Zone in the Twin Screw Extruder on the Properties of Amorphous Solid Dispersion of Ritonavir

A ternary amorphous solid dispersion (ASD) system consisting of drug/polymer/surfactant is receiving increased attention to improve the oral bioavailability of poorly water-soluble drugs. The effect of polymers has been extensively studied, while the impact of surfactants has not yet to be studied t...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Hengqian Wu, Zhengping Wang, Yanna Zhao, Yan Gao, Heng Zhang, Lili Wang, Zhe Wang, Jun Han
Format:	Article
Language:	English
Published:	MDPI AG 2023-01-01
Subjects:	amorphous solid dispersion hot-melt extrusion ritonavir Span 20 precipitation
Online Access:	https://www.mdpi.com/1999-4923/15/2/441