An explanation for origin unwinding in eukaryotes

Twin CMG complexes are assembled head-to-head around duplex DNA at eukaryotic origins of replication. Mcm10 activates CMGs to form helicases that encircle single-strand (ss) DNA and initiate bidirectional forks. How the CMGs melt duplex DNA while encircling it is unknown. Here we show that S. cerevi...

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Bibliographic Details
Published in:eLife
Main Authors: Lance D Langston, Michael E O'Donnell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Subjects:
helicase
replication origin
DNA replication
Online Access:https://elifesciences.org/articles/46515

Internet

https://elifesciences.org/articles/46515

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