Kinome state is predictive of cell viability in pancreatic cancer tumor and cancer-associated fibroblast cell lines

Numerous aspects of cellular signaling are regulated by the kinome—the network of over 500 protein kinases that guides and modulates information transfer throughout the cell. The key role played by both individual kinases and assemblies of kinases organized into functional subnetworks leads to kinom...

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Bibliographic Details

Published in:	PeerJ
Main Authors:	Matthew E. Berginski, Madison R. Jenner, Chinmaya U. Joisa, Gabriela Herrera Loeza, Brian T. Golitz, Matthew B. Lipner, Jack R. Leary, Naim Rashid, Gary L. Johnson, Jen Jen Yeh, Shawn M. Gomez
Format:	Article
Language:	English
Published:	PeerJ Inc. 2024-08-01
Subjects:	Cancer Cell signaling Machine learning Predictive modeling Drug response Kinase inhibitor treatment
Online Access:	https://peerj.com/articles/17797.pdf