Fibre supplementation alters the gastrointestinal microbiome, the microbial metabolites and indicators of neurodegeneration in a mouse model of Alzheimer´s disease

Abstract Alzheimer´s disease is a neurodegenerative disease with high global prevalence and no cure available. It is known that the microbiota-gut-brain-axis plays a role in the pathogenesis, but the pathways are not fully understood yet. To elucidate the role of dietary fibre supplementation on thi...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Linda F. Böswald, Jasmin Wenderlein, Martin Bachmann, Annette Zeyner, Klaus Neuhaus, Frederike Schäfer, Axel Imhof, Shibojyoti Lahiri, Josephine Gruetzke, Bastian Popper
Format: Article
Language:English
Published: Nature Portfolio 2025-09-01
Subjects:
Inulin
Prebiotic
Microbiota
SCFA
Neurology
5xFAD mouse
Online Access:https://doi.org/10.1038/s41598-025-20986-8

Internet

https://doi.org/10.1038/s41598-025-20986-8

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