Neoantigen prioritization based on antigen processing and presentation

Somatic mutations in tumor cells give rise to mutant proteins, fragments of which are often presented by MHC and serve as neoantigens. Neoantigens are tumor-specific and not expressed in healthy tissues, making them attractive targets for T-cell-based cancer immunotherapy. On the other hand, since m...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Serina Tokita, Takayuki Kanaseki, Toshihiko Torigoe
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-11-01
Subjects:	neoantigen MHC antigen processing and presentation personalized medicine cancer vaccine
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1487378/full