Structural Adaptation of the Single-Stranded DNA-Binding Protein C-Terminal to DNA Metabolizing Partners Guides Inhibitor Design

Single-stranded DNA-binding protein (SSB) is a bacterial interaction hub and an appealing target for antimicrobial therapy. Understanding the structural adaptation of the disordered SSB C-terminus (SSB-Ct) to DNA metabolizing enzymes (e.g., ExoI and RecO) is essential for designing high-affinity SSB...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Attila Tököli, Brigitta Bodnár, Ferenc Bogár, Gábor Paragi, Anasztázia Hetényi, Éva Bartus, Edit Wéber, Zsófia Hegedüs, Zoltán Szabó, Gábor Kecskeméti, Gerda Szakonyi, Tamás A. Martinek
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Subjects:	intrinsically disordered proteins single-stranded DNA-binding protein peptide non-natural amino acid antimicrobial
Online Access:	https://www.mdpi.com/1999-4923/15/4/1032