Folding of prestin’s anion-binding site and the mechanism of outer hair cell electromotility

Prestin responds to transmembrane voltage fluctuations by changing its cross-sectional area, a process underlying the electromotility of outer hair cells and cochlear amplification. Prestin belongs to the SLC26 family of anion transporters yet is the only member capable of displaying electromotility...

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Bibliographic Details

Published in:	eLife
Main Authors:	Xiaoxuan Lin, Patrick R Haller, Navid Bavi, Nabil Faruk, Eduardo Perozo, Tobin R Sosnick
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2023-12-01
Subjects:	mass spectrometry hydrogen exchange cochlear amplification protein folding voltage sensing cryo-electron microscopy
Online Access:	https://elifesciences.org/articles/89635