The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice

Abstract Background Ubiquitination is a post-translational modification required for a number of physiological functions regulating protein homeostasis, such as protein degradation. The endoplasmic reticulum (ER) quality control system recognizes and degrades proteins no longer needed in the ER thro...

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Bibliographic Details

Published in:	BMC Biology
Main Authors:	Kaori Nozawa, Yoshitaka Fujihara, Darius J. Devlin, Ricardo E. Deras, Katarzyna Kent, Irina V. Larina, Kohei Umezu, Zhifeng Yu, Courtney M. Sutton, Qiuji Ye, Laura K. Dean, Chihiro Emori, Masahito Ikawa, Thomas X. Garcia, Martin M. Matzuk
Format:	Article
Language:	English
Published:	BMC 2022-07-01
Subjects:	Sperm defects ERAD Male infertility Contraceptive PROTACs
Online Access:	https://doi.org/10.1186/s12915-022-01368-2