Protective role of CXCR7 activation in neonatal hyperoxia-induced systemic vascular remodeling and cardiovascular dysfunction in juvenile rats

Abstract Neonatal hyperoxia induces long-term systemic vascular stiffness and cardiovascular remodeling, but the mechanisms are unclear. Chemokine receptor 7 (CXCR7) represents a key regulator of vascular homeostasis and repair by modulating TGF-β1 signaling. This study investigated whether pharmaco...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Merline Benny, Mayank Sharma, Shathiyah Kulandavelu, PingPing Chen, Runxia Tian, Sydne Ballengee, Jiang Huang, Amanda F. Levine, Matteo Claure, Augusto F. Schmidt, Roberto I. Vazquez-Padron, Claudia O. Rodrigues, Shu Wu, Omaida C. Velazquez, Karen C. Young
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-11-01
Online Access:	https://doi.org/10.1038/s41598-023-46422-3