Proteogenomic characterisation of primary oral cancer unveils extracellular matrix remodelling and immunosuppressive microenvironment linked to lymph node metastasis

Abstract Oral squamous cell carcinoma (OSCC) is an increasingly prevalent malignancy worldwide. This study aims to understand molecular alterations associated with lymph node metastasis of OSCC in order to improve treatment strategies. We analysed a cohort of 46 patients with primary OSCC, including...

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Bibliographic Details

Published in:	Clinical and Translational Medicine
Main Authors:	Yu Liu, Zhenyu Yang, Jingya Jane Pu, Jie Zhong, Ui‐Soon Khoo, Yu‐Xiong Su, Gao Zhang
Format:	Article
Language:	English
Published:	Wiley 2025-03-01
Subjects:	lymph node metastasis oral squamous cell carcinoma single‐cell analysis
Online Access:	https://doi.org/10.1002/ctm2.70261